2024 Breast cancer single cell atlas

Breast cancer single cell atlas

Author: agud

August undefined, 2024

WebDec 2, 2024 · Herein, we present matched transcriptome (scRNA-seq) and chromatin accessibility (scATAC-seq) profiles at single-cell resolution from human ovarian and endometrial tumors processed immediately following surgical resection. WebJun 5, 2024 · June 5, 2024 Dataset Open Access A single-cell and spatially resolved atlas of human breast cancers spatial transcriptomics data Sunny Z Wu; Alexander Swarbrick This repository contains spatial transcriptomics data related to the Wu et al. 2024 study " A single-cell and spatially resolved atlas of human breast cancers ".

A single-cell atlas of breast cancer cell lines to study tumour ...

WebFeb 25, 2024 · To investigate immunological features of TME and their associations with clinical characteristics of breast cancer, Wagner et al. provided a large-scale single-cell atlas of the human breast cancer tumor microenvironment by analyzing 144 human BRCA tumors covering all clinical subtypes and 50 non-tumor tissue samples by using single … WebMay 5, 2024 · Single-cell transcriptome analyses profile > 340,000 cells encompassing normal breast, preneoplastic BRCA1 +/– tissue, the … nazda alam foundation

A single cell atlas pieces together the puzzling …

WebSep 6, 2024 · Nature Genetics - A multi-omic atlas of breast cancers, integrating single-cell RNA sequencing, spatial transcriptomics and immunophenotyping, identifies nine ecotypes associated with cellular... We would like to show you a description here but the site won’t allow us. WebDec 13, 2024 · Here, we leverage single-cell RNA-sequencing (RNA-seq) and ATAC-sequencing (ATAC-seq) technologies to characterize the cellular and molecular dynamics of immune cells in 22 patients with TNBC treated with paclitaxel or … WebJul 25, 2024 · Overexpression and hyperactivation of the serine/threonine protein kinase B (AKT) pathway is one of the most common cellular events in breast cancer progression. However, the nature of AKT1-specific genome-wide transcriptomic alterations in breast cancer cells and breast cancer remains unknown to this point. Here, we delineate the … mark wirth death

AKT1 Transcriptomic Landscape in Breast Cancer Cells

A human breast atlas integrating single-cell proteomics …

WebA Single-Cell Proteomic Atlas of Breast Cancer Ecosystems We performed large-scale mass cytometry profiling of 144 prospectively collected tumor samples, including 54 luminal A, 71 luminal B, six luminal B-HER2 +, one HER2 +, and six TN tumors ( Tables S1 and S2; Coates et al., 2015 ). Web19 hours ago · Breast cancer; Cardiovascular disease ... Researchers generated the atlas using 54 tissue and cell types compiled after death from 948 individuals who ... "Going from a single cell to a child is a ... nazdar 8450 barrier whiteWebTherefore a more detailed transcriptional atlas of breast tumors at high molecular resolution, representative of all subtypes and cell types, is required to further define the taxonomy of the disease, identify heterotypic cellular interactions and determine cellular differentiation events. ... Deconvolution of breast cancer cohorts using single ... nazdar 9600 series tech sheet

"WebApr 23, 2024 · The Cancer Genome Atlas-Breast Cancer (TCGA-BRCA) and single-cell RNA-seq from GSE75688 were retrospectively reviewed. Kaplan–Meier survival curves, univariate and multivariate analysis based on Cox regression model were conducted for survival analysis. Gene set enrichment analysis (GSEA) and single-cell cellular … " - Breast cancer single cell atlas

Breast cancer single cell atlas

A single-cell atlas of breast cancer cell lines to study tumour ...

WebSingle-cell RNA sequencing (scRNA-seq) is a novel technology that allows transcriptomic analyses of individual cells. During the past decade, scRNA-seq sensitivity, accuracy, and efficiency have improved due to innovations including more sensitive, automated, and cost-effective single-cell isolation … WebIntroduction. Breast cancer (BC) is the leading cause of cancer deaths among females worldwide, with an estimated >500,000 deaths occurring in 2012. 1 As the incidence of BC is increasing rapidly, 2 understanding the biological mechanisms involved and exploring novel targets are urgently needed. EF-hand proteins are a large number of Ca2 + …

Did you know?

WebTo characterize features of breast cancer ecosystems and their associations with clinical data, we analyzed 144 human breast tumor and 50 non-tumor tissue samples using mass cytometry. The expression of 73 proteins in 26 million cells was evaluated using tumor and immune cell-centric antibody panels. WebNational Center for Biotechnology Information

WebJun 2, 2024 · The lineage-specific genes infer cells of origin of breast cancer using The Cancer Genome Atlas data and single-cell RNA sequencing of human breast cancer, as well as the association of gland ... WebSingle cell type. Showing cell type specific RNA data of ADARB2 (ADAR3, hRED2, RED2). ... Cancer Prognosis. Cancer ... ADIPOSE TISSUE BONE MARROW BRAIN BREAST BRONCHUS COLON ENDOMETRIUM ESOPHAGUS EYE HEART MUSCLE. KIDNEY LIVER LUNG LYMPH NODE OVARY PANCREAS PBMC PLACENTA PROSTATE …

WebFeb 1, 2024 · Single Cell Breast Cancer cell-line Atlas. Cite. (1.8 GB) Version 2. Version 2 2024-02-01, 02:32. Version 1 2024-01-28, 08:09. dataset. posted on 2024-02-01, 02:32 authored by Gennaro Gambardella. Raw UMI counts of 35,276 single cell across 32 Breast Cancer Cell-lines profiled with DROP-seq platform. WebOct 3, 2024 · Read our blog to explore single cell findings from the most detailed breast cell atlas generated to date. ... Cheng S, et al. A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid …

WebApr 12, 2024 · Background Metastasis, the leading cause of cancer-related death in patients diagnosed with ovarian cancer (OC), is a complex process that involves multiple biological effects. With the continuous development of sequencing technology, single-cell sequence has emerged as a promising strategy to understand the pathogenesis of …

WebJun 6, 2024 · We present a unified, high-resolution breast atlas by integrating single-cell RNA-seq, mass cytometry, and cyclic immunofluorescence, encompassing a myriad of states. We define cell subtypes within the alveolar, hormone-sensing, and basal epithelial lineages, delineating associations of several subtypes with cancer risk factors, including … mark wise credit cardWebSep 6, 2024 · Using single cell signatures, we deconvoluted large breast cancer cohorts to stratify them into nine clusters, termed ‘ecotypes’, with unique cellular compositions and clinical outcomes. This study provides a comprehensive transcriptional atlas of the cellular architecture of breast cancer. naz community hallWebA core mission of cancer genomics is to comprehensively chart molecular underpinnings of cancer-driving events and to provide personalized therapeutic strategies. Primarily focused on cancer cells, cancer genomics studies have successfully uncovered many drivers for major cancer types. Since the emergence of cancer immune evasion as a critical ... markwin under eye cream reviewWebFeb 1, 2024 · Figure 1 – The Breast Cancer Single Cell Atlas. (A) Representation of single-cell expression profiles of 35,276 cells from 32 cell lines color-coded according to cancer subtype (LA=Luminal A, … mark witas sermonsWebUsing single-cell signatures, we deconvoluted large breast cancer cohorts to stratify them into nine clusters, termed ‘ecotypes’, with unique cellular compositions and clinical outcomes. This study provides a comprehensive transcriptional atlas of the cellular architecture of breast cancer. nazdar color matchingWebApr 6, 2024 · Breast cancer single-cell atlas. (A) Flowchart of identifying prognostic cells using combined single-cell and bulk data. (B) The UMAP cluster diagram shows the different cell types of breast cancer. (C) Bubble chart shows specific markers corresponding to different cell types. (D) Unsupervised cluster heat map of tumor … mark wirth nycWebJan 4, 2024 · We generated a Breast Cancer Single-Cell Cell Line Atlas (BSCLA) to help inform future BC research. We sequenced over 36,195 cells composed of 13 cell lines spanning the spectrum of clinical BC subtypes and leveraged publicly available data comprising 39,214 cells from 26 primary tumors. markwithai