Fat mass mendelian randomization
WebApr 11, 2024 · Abstract. Background: The association between fat mass and mortality has been equivocally shown to be linear, J-shaped, and U-shaped. We aimed to clarify this relationship based on Mendelian randomization (MR) analysis and lifestyle modification. WebJan 21, 2024 · Purpose The causal effects of body fat mass and body fat-free mass on coronavirus disease 2024 (COVID-19) severity remain unclear. Here, we used Mendelian randomization (MR) to evaluate the causal relationships between body fat-related traits and COVID-19 severity. Material and Methods We identified single nucleotide …
Fat mass mendelian randomization
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WebBackground: The association between fat mass and mortality has been equivocally shown to be linear, J-shaped, and U-shaped. We aimed to clarify this relationship based on … WebJun 13, 2024 · The causal role of adiposity for several cardiovascular diseases (CVDs) is unclear. Our primary aim was to apply the Mendelian randomization design to investigate the associations of body mass index (BMI) with 13 CVDs and arterial hypertension. We also assessed the roles of fat mass and fat-free mass on the same outcomes.
WebJun 30, 2024 · Fat mass and fat-free mass are found to be associated with different health outcomes in observational studies, but the underlying causality remains unclear. We aimed to investigate the causal relationships between body composition and cardiometabolic traits using a two-sample Mendelian randomization (MR) approach. WebNov 12, 2024 · Mendelian randomization (MR) analysis uses functional polymorphisms (single nucleotide polymorphisms (SNPs)) associated with specific changes in exposures (in this case, serum 25 (OH) D) as genetic instruments to determine whether the risk factor is a cause of the disease ( 21 ).
WebAlcoholic liver disease was consistently associated with WC even after adjusting for alcohol consumption in a multivariable Mendelian randomization analysis. The odds ratio per 1-SD increase in genetically predicted WC (12.52 cm) for such associations ranged from 1.41 (95% CI: 1.17–1.70; p = 0.0015) for gastric cancer to 1.74 (95% CI: 1.21 ... WebIn this study, Granell and colleagues used Mendelian randomization to investigate causal effects of BMI, fat mass, and lean mass on current asthma at age 7½ years in the Avon …
WebBackgroundCirculating vitamin D has been associated with multiple clinical diseases in observational studies, but the association was inconsistent due to the presence of confounders. We conducted a bidirectional Mendelian randomization (MR) study to explore the healthy atlas of vitamin D in many clinical traits and evaluate their causal …
Web2 days ago · A phenome-wide Mendelian randomization (MR) study of anti-VZV immunoglobulin G (IgG) levels with 1370 traits was conducted to explore the potential causal role of VZV-specific immune response on multiple traits using the UK Biobank cohort. ... disability, or infirmity. Anti-VZV IgG also showed a positive causal effect on body fat … prince2 foundation en practitioner eindhovenWebEnter the email address you signed up with and we'll email you a reset link. prince2 foundation en practitioner groningenWebEnter the email address you signed up with and we'll email you a reset link. prince2 foundation en practitioner emmenWebIn the absence of large-scale RCTs, Mendelian randomization (MR) is a method that offers improved causal inference by utilizing human germline genetic variation (usually, single … prince2 foundation en practitioner edeWebChildhood: A Mendelian Randomization Study Raquel Granell1*, A. John Henderson1, David M. Evans2,3, George Davey Smith2, Andrew R. Ness4,5, ... of fat mass and lean mass included in the analyses were calculated as the residuals from a linear regression of each on gender, height, prince2 foundation certificaatWebMethods We selected 12 single-nucleotide polymorphisms (SNPs) associated with body mass index (BMI)-adjusted fasting insulin levels and 5 SNPs associated with gold standard measures of insulin resistance as instrumental variables in Mendelian randomization (MR) analyses. Summary statistical data of SNP-small vessel stroke and of SNP-AD ... prince2 foundation en practitioner deventerWebMean weight loss was 5.1 kg for those who completed the 12-week program. There were no significant differences in total weight, fat, or lean body mass loss when compared by diet … prince2 foundation en practitioner haarlem