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Magi3 gene

WebMagi3, Fzd4, and Ltap independently localized to sites of cell-cell contacts in epithelial cells, and these 3 proteins interacted in a complex that required Magi3. Magi3 strongly … WebMay 25, 2024 · Our findings lend support to a genetic basis for modulation of intestinal epithelial barrier in IBD, and we have identified MAGI3 as a new candidate gene for IBD. …

MAGI3 protein expression summary - The Human Protein Atlas

WebJul 22, 2024 · MAGI3 was identified as a novel substrate-binding subunit of SKP1-Cullin E3 ligase to recognize c-Myc, and process c-Myc ubiquitination and degradation. Expression of MAGI3 in CRC cells inhibited cell growth, promoted apoptosis and chemosensitivity to fluoropyrimidine-based chemotherapy by suppressing activation of c-Myc in vitro and in … WebFeb 13, 2024 · MGI is the international database resource for the laboratory mouse, providing integrated genetic, genomic, and biological data to facilitate the study of human health and disease. About Us MGI Publications Cite Us 1 2 3 4 5 6 What's new at MGI updated February 13, 2024 QTL Detail Pages now include candidate genes and QTL … focus for mothers fort worth https://clarionanddivine.com

MAGI3–AKT3 fusion gene. a, Diagram of balanced …

WebOfficial gene symbol, which is typically a short form of the gene name, according to HGNC. MAGI3 (MAGI-3) Protein classi. Assigned HPA protein class (es) for the encoded protein (s). Read more. Number of transcriptsi. Number of protein-coding transcripts from the gene as defined by Ensembl. 4. WebMar 28, 2024 · Function. Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to … WebDownload scientific diagram A network consisting of seven TJ genes (F11R, MAGI1, MAGI2, MAGI3, PARD3, PTEN, and TJP1) identified using the STRING search tool [14, 15] from publication: Genetic ... focus ford wikipedia

MAGI3 membrane associated guanylate kinase, WW …

Category:E3 ubiquitin ligase MAGI3 degrades c-Myc and acts as a …

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Magi3 gene

Expression of MAGI3 in cancer - Summary - The Human Protein …

WebOct 13, 2024 · Magi3 membrane associated guanylate kinase, WW and PDZ domain containing 3 [ (house mouse)] Gene ID: 99470, updated on 13-Oct-2024 Summary … WebMar 21, 2024 · Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and SMAD binding . An important paralog of this gene is MAGI3. UniProtKB/Swiss-Prot Summary for MAGI2 Gene Seems to act as a scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins …

Magi3 gene

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WebMay 20, 2016 · Premature polyadenylation of MAGI3 is a recurrent, tumor-specific event in breast cancer. ( A) Summary of RNA-Seq analysis, statistical tests, and thresholds used to identify primary tumor and matched, tumor-adjacent normal samples expressing MAGI3pPA. Genome coverage of total mappable … see more … WebJul 22, 2024 · MAGI3 was identified as a novel substrate-binding subunit of SKP1-Cullin E3 ligase to recognize c-Myc, and process c-Myc ubiquitination and degradation. …

http://www.informatics.jax.org/marker/MGI:1923484 WebDec 8, 2024 · The altered mRNA isoform, called MAGI3(pPA), produces a truncated protein that acts in a dominant-negative manner to prevent full-length MAGI3 from interacting …

WebSequence variants and/or copy number variants (deletions/duplications) within the MAGI3 gene will be detected with >99% sensitivity. Variants classified as unknown significance … WebApr 16, 2015 · MAGI3-AKT3 fusion results in the constitutive activation of AKT kinase, and it is now considered a possible target for ATP-competitive AKT small-molecule inhibitors [94]. However, the apparent...

WebPubMed: MAGI3 [Title/Abstract] AND NOTCH2 [Title/Abstract] AND fusion [Title/Abstract] Functional or gene categories assigned by FusionGDB annotation: Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.

WebMAGI3 is part of cluster 38 Neurons - Neuronal signaling with confidence i Confidence is the fraction of times a gene was assigned to the cluster in repeated clustering, and therefore … focus for macWebMembrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 is an enzyme that in humans is encoded by the MAGI3 gene.[5][6][7] For faster navigation, this Iframe is preloading the Wikiwand page for MAGI3 . focus for studyingWebApr 15, 2015 · To make the assumption that MAGI3–AKT3 fusion was a recurrent event in TNBC, Banerji et al. 1 interrogated their tumours by using RT–PCR of cDNA followed by … focus for studentsWebExpression of MAGI3 (MAGI-3) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. ... MAGI3: Gene description i. Membrane associated guanylate kinase, WW and PDZ domain containing 3: Predicted location i Intracellular: Number of ... focus for studyWebMAGI3 has 3,677 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 69 datasets. focus forward accountingWebBottom, cDNA PCR of fusion gene in tumour. c, Above, MAGI3 and AKT3 protein domains; below, putative fusion protein. d, Immunoblots of lysates from ZR-75 cells transfected with vector,... focus forward addressWebNov 6, 2024 · MAGI3provided by HGNC Official Full Name membrane associated guanylate kinase, WW and PDZ domain containing 3provided by HGNC Primary source … focus forward address page