Spike ferritin nanoparticle platform
WebNational Center for Biotechnology Information WebSep 9, 2024 · This mRNA vaccine based on the encoded self-assembled nanoparticle-based trimer RBD provides a reference for the design of mRNA vaccines targeting SARS-CoV-2. Highlights 1. Nanoparticle-based...
Spike ferritin nanoparticle platform
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WebWe evaluated whether a spike ferritin nanoparticle vaccine (SpFN), adjuvanted with the Army Liposomal Formulation QS21 (ALFQ), conferred protection against the B.1.1.7 and B.1.351 VOCs in Syrian ... WebJan 11, 2024 · The US Army has recently developed a SARS-CoV-2 sub-unit vaccine based on a ferritin nanoparticle platform that displays a pre-fusion stabilized spike on its surface [1]. The spike protein was modified to generate a stable …
WebFerritin nanoparticles carrying HPV16 oncogene E7 peptide antigen or MC38 tumor derived mutant neoantigens elicit about 2-3 folds enhanced antigen-specific cytotoxic T lymphocyte (CTL) response than soluble peptide antigens and significantly suppress the growth of E7-related or MC38 tumors. WebJan 27, 2024 · Ferritin is an attractive nanoparticle platform for production of vaccines, and ferritin-based vaccines have been investigated in humans in two separate clinical trials. …
WebDec 16, 2024 · A SARS-CoV-2 nanoparticle vaccine was designed and administered to NHPs The SpFN vaccine was designed as a ferritin-fusion recombinant protein for expression … WebMar 30, 2024 · In the continued need for next-generation vaccines that confer broad protection against COVID-19, scientists developed an adjuvanted SARS-CoV-2 Spike Ferritin Nanoparticle (SpFN) vaccine.
WebJun 11, 2024 · LuS and ferritin coupled to SpyTag expressed well in a mammalian expression system when ... murine vaccination with the SARS-CoV-2 spike-LuS nanoparticles elicited ~25-fold higher neutralizing responses, weight-per-weight relative to spike alone. The versatile platform described here thus allows for multivalent plug-and …
WebApr 3, 2024 · In this report, we describe formulation development and comparability studies with a self-assembled SARS-CoV-2 spike ferritin nanoparticle vaccine antigen (called DCFHP), when produced in two ... poly phan obituaryWebMar 2, 2024 · Here, we demonstrate the immunogenic efficacy of the self-assembling spike RBD-ferritin nanoparticle (RBD-nanoparticle) as an efficient SARS-CoV-2 vaccine antigen. … shannan and chris watts weddingWebMay 4, 2024 · Here, we report on the immunogenicity and efficacy of a SARS-CoV-2 vaccine comprising stabilized, pre-fusion spike protein trimers displayed on a ferritin nanoparticle (SpFN) adjuvanted with either conventional aluminum hydroxide or the Army Liposomal Formulation QS-21 (ALFQ) in a cynomolgus macaque COVID-19 model. polyphagia medical terminology imagesWebJun 1, 2024 · A previous study developed a SARS-CoV-2 vaccine based on a virus-like nanoparticle (VLP) platform, in which sixty copies of a fusion protein including a receptor binding domain (RBD) with a ... shanna moakler wedding dressWebMar 30, 2024 · The use of ferritin nanoparticles is one new method to increase immune responses against a relevant antigen, such as spike (S) glycoprotein. The S glycoprotein of SARS-CoV-2 is located on the... shannan butlerWebMar 2, 2024 · Development of Spike Receptor-Binding Domain Nanoparticles as a Vaccine Candidate against SARS-CoV-2 Infection in Ferrets - PMC Back to Top Skip to main content An official website of the United States government Here's how you know The .gov means it’s official. Federal government websites often end in .gov or .mil. shanna murthyWebApr 5, 2024 · Scientists developed a nanoparticle vaccine, based on a ferritin platform, which offers a flexible approach to targeting multiple variants of SARS-COV-2 and … shannan and chris watts wedding photos